Compounds and compositions as hedgehog pathway inhibitors
US8507491B2 · kind B2 · utility
9Cited by
0References
18Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Aug 24, 2009 |
| Grant date | Aug 13, 2013 |
| Priority date | — |
| Expiry date | Dec 18, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D513/04
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The invention provides a method, compounds and compositions for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or GIi gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula (I).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.