4, 6-disubstituted aminopyrimidine derivatives as inhibitors of protein kinases

US8507498B2 · kind B2 · utility

Assignee

• Ingenium Pharmaceuticals GmbH · DE

Inventors

• Philipp Wabnitz · Düsseldorf, DE
• Heike Schauerte · Munich, DE
• Hans Allgeier
• Martin Augustin · Herrsching am Ammersee, DE
• Lutz Zeitlmann · Munich, DE
• Michael A. Pleiss · Sunnyvale, US
• Gabriele Stumm · Unterhaching, DE
• Anke Mueller · Germering, DE
• Axel Choidas · Herdecke, DE
• Bert Klebl · Dortmund, DE
• Gerhard Mueller · Leverkusen, DE
• Wilfried Schwab · Altentreptow, DE
• Joelle Le · Stevenage, GB
• Jackie Macritchie · Saffron Walden, GB
• Don Simpson · Haverhill, GB

Key dates

• Filing date: Apr 24, 2008
• Grant date: Aug 13, 2013
• Expiry date: Apr 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D409/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to inhibitors of general Formula (I) of cyclin-dependent kinases and therapeutic applications thereof. Furthermore, the invention relates to compounds for preventing and/or treating any type of pain, inflammatory disorders, immunological diseases, proliferative diseases, infectious diseases, cardiovascular diseases and neurodegenerative diseases.