Process for preparing 5,7 diaminopyrazolo [1,5-A] pyrimidine compounds

US8507673B2 · kind B2 · utility

Assignees

• EMORY UNIVERSITY · US
• Imperial College of Science and Technology · GB

Inventors

• Dennis C. Liotta · Atlanta, US
• James P. Snyder · Atlanta, US
• Ashutosh S. Jogalekar · Redwood City, US
• Anthony Barrett · London, GB
• Matthew Fuchter · London, GB
• Matthew J. Cook · Foxford, IE
• Sebastian Kroll · Hertford, GB

Key dates

• Filing date: Jun 9, 2011
• Grant date: Aug 13, 2013
• Expiry date: Jun 9, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Processes for the preparation of certain 5,7-diaminopyrazolo[1,5-α]pyrimidine compounds comprising the reaction of a primary or secondary amine and a protected 5-halo-7-aminopyrazolo[1,5-α]pyrimidine compound in solvent system comprising water and one or more organic solvents, optionally in the presence of an exogenous base.