N and/or Nα derivatized, metal and organic protected L-histidine for coupling to biomolecules for highly efficient labeling with [M(OH2)3 (CO)3]+ by fac coordination
US8512675B2 · kind B2 · utility
1Cited by
5References
7Claims
0Family size
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Key dates
| Filing date | Apr 29, 2004 |
| Grant date | Aug 20, 2013 |
| Priority date | — |
| Expiry date | Jun 2, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N33/68
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
The present invention relates to novel histidine derivates that can be used for the labeling of biomolecules with radioactive metal tricarbonyls. The new derivatives have a histidine that is derivatized at the Nε and at least protected at the Nα and optionally at the Nδ; or derivatized at the Nα and at least protected at the Nα and optionally at the Nδ; or derivatized at the Nε and Nα and at least protected at the Nα and optionally at the Nδ; or derivatized at the Nε; or derivatized at the Nα; or derivatized at the Nε and Nα; or at least protected at the Nα and optionally at the Nδ.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.