Patent · US Active

Polyvinyl formamide (PNVF) and polyvinyl amine (PVAm)nanoparticles, nanocapsules and nanogels

US8512862B2 · kind B2 · utility

5Cited by
9References
19Claims
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Key dates

Filing dateAug 4, 2011
Grant dateAug 20, 2013
Priority date—
Expiry dateAug 4, 2031

Classification

  • Technology area (CPC Y)Emerging Cross-Sectional Technologies
  • CPC primaryY10T428/2998
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Acid-labile poly(N-vinyl formamide) (“PNVF”) nanocapsules were synthesized by free radical polymerization of N-vinyl formamide with optional active ingredients on the surface of silica nanoparticles. Polymerization in the presence of a novel cross-linker that contains an acid-labile ketal facilitated stable etching of silica nanoparticle templates using sodium hydroxide and recovery of PNVF nanocapsules. The formamido side group of PNVF was then hydrolyzed by extended exposure to sodium hydroxide to produce polyvinylamine (“PVAm”) nanocapsules. PNVF and PVAm nanoparticles are also synthesized that form nanogels with optional active ingredients.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.