Patent · US Active

Potent chimeric NRTI-NNRTI bifunctional inhibitors of HIV-1 reverse transcriptase

US8513205B2 · kind B2 · utility

2Cited by

0References

33Claims

0Family size

Assignees

Yale University · US
UNIVERSITY OF CAPE TOWN · ZA

Inventors

Karen Anderson · Guilford, US
Roger Hunter · Bakersfield, US

Key dates

Filing date	Apr 9, 2009
Grant date	Aug 20, 2013
Priority date	—
Expiry date	Feb 1, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07F9/65586
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present invention relates to compounds, in particular, dual antagonists comprising a nucleoside reverse transcriptase inhibitor (NRTI) or a nucleoside competitive reverse transcriptase inhibitor and a non-nucleoside reverse transcriptase inhibitor (NNRTI), linked together using a chemical linker, which may be used to inhibit HIV (HIV-1) reverse transcriptase and in the treatment of HIV infections, more severe cases of HIV infections, including ARC and AIDS, including reducing the likelihood of these infections and disease states.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.