Patent · US Active

Micro-RNAS of the MIR-15 family modulate cardiomyocyte survival and cardiac repair

US8513209B2 · kind B2 · utility

2Cited by

4References

27Claims

0Family size

Assignee

The Board of Regents of the University of Texas System · US

Inventors

Eric Olson · Dallas, US
Eva van Rooij · Utrecht, NL

Key dates

Filing date	Nov 10, 2008
Grant date	Aug 20, 2013
Priority date	—
Expiry date	Nov 10, 2028

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2830/008
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

A family of microRNAs, called the miR-15 family, which includes miR-195, are shown to be up-regulated during pathological cardiac remodeling and repress the expression of mRNAs required for cell proliferation and survival, with consequent loss of cardiomyocytes. Strategies to block expression of the miR-15 family in the heart as a treatment for diverse cardiac disease are provided.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.