C4′-substituted-2-deoxyadenosine analogs and methods of treating HIV

US8513214B2 · kind B2 · utility

Assignee

• The United States of America as represented by the Secretary of the Dept. of Health & Human Services · US

Inventors

• Bao-Han C. Vu · Frederick, US
• Maqbool A. Siddiqui · Rockville, US
• Victor E. Marquez · Gaithersburg, US
• Stephen H. Hughes · Smithsburg, US
• Paul Boyer · Greencastle, US

Key dates

• Filing date: Nov 10, 2008
• Grant date: Aug 20, 2013
• Expiry date: Apr 14, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07H19/16
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides for novel 2-Deoxyadenosine compounds, which can treat HIV infection at low cytotoxicity values. Substitution at the 4′-position provided compounds which demonstrated low cytotoxicity values in an ATP-based cytotoxicity assay.