α-(N-sulfonamido)acetamide derivatives as β-amyloid inhibitors

US8513253B2 · kind B2 · utility

Assignee

• Bristol-Myers Squibb Company · US

Inventors

• Michael F. Parker · Higganum, US
• Katharine E. McElhone · San Diego, US
• Robert A. Mate · Waterbury, US
• Joanne J. Bronson · Madison, US
• Yonghua Gai · North Grafton, US
• Carl P. Bergstrom · Madison, US
• Lawrence R. Marcin · Bethany, US
• John E. Macor · Guilford, US

Key dates

• Filing date: Jul 21, 2010
• Grant date: Aug 20, 2013
• Expiry date: Jul 8, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/14
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I)wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.