Topical formulation

US8513304B2 · kind B2 · utility

Assignee

• Nuvo Research Inc. · CA

Inventors

• Edward T. Kisak · San Diego, US
• John M. Newsam · Village of La Jolla, US
• Dominic King-Smith · San Diego, US
• Pankaj Karande · Troy, US
• Samir Mitragotri · Goleta, US

Key dates

• Filing date: Nov 19, 2012
• Grant date: Aug 20, 2013
• Expiry date: Nov 19, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

It has been discovered that certain combinations of compounds are excellent penetration enhancers and, as such, can be incorporated in a topical formulation to facilitate administration of active agents. The increased penetration enhancement can also lead to a reduction in the total concentration of skin irritants in the formulation. There is described herein a topical formulation comprising (i) an active agent selected from at least one of lidocaine and tetracaine; (ii) a first compound, and (iii) a second compound, wherein the first compound and second compound are different, and each is selected from the group consisting of N-lauroyl sarcosine, sodium octyl sulfate, methyl laurate, isopropyl myristate, oleic acid, glyceryl oleate and sodium lauryl sulfoacetate.