Double stranded nucleic acid targeting low copy promoter-specific RNA
US8513401B2 · kind B2 · utility
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3References
14Claims
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Key dates
| Filing date | May 3, 2010 |
| Grant date | Aug 20, 2013 |
| Priority date | — |
| Expiry date | Jul 26, 2031 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2310/53
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention relates to transcriptional gene silencing (TGS) in mammalian, including human, cells that is mediated by small interfering RNA (siRNA) molecules. The present invention also relates to a double stranded nucleic acid that directs methylation of histones associated with target genes that produce low copy promoter-specific RNA. It has been found that siRNAs can be used to direct methylation of histones in mammalian, including human, cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.