Piperidin-4-yl-azetidine diamides as monoacylglycerol lipase inhibitors

US8513423B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Peter J. Connolly · New Providence, US
• Haiyan Bian · Princeton, US
• Xun Li · Huizhou, CN
• Li Liu · Doylestown, US
• Mark J. Macielag · Spring House, US
• Mark McDonnell · Lansdale, US

Key dates

• Filing date: Oct 20, 2011
• Grant date: Aug 20, 2013
• Expiry date: Oct 20, 2031

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P25/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows:wherein Y, Z, and R are defined herein.