Patent · US Active

Substituted thiazol-2-ylamine derivatives, pharmaceutical compositions, and methods of use as 11-beta HSD1 modulators

US8513430B2 · kind B2 · utility

0Cited by

24References

41Claims

0Family size

Assignee

High Point Pharmaceuticals, LLC · US

Inventors

Dharma Rao Polisetti · High Point, US
Suparna Gupta · Greensboro, US

Key dates

Filing date	Jul 25, 2011
Grant date	Aug 20, 2013
Priority date	—
Expiry date	Oct 24, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07D417/12
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to substituted thiazol-2-ylamine derivatives and pharmaceutically acceptable salts thereof that inhibit 11βHSD1 and that may be useful in the treatment of diseases in which modulation or inhibition of 11βHSD1 is beneficial or where a reduction in intracellular glucorticoid levels is desirable. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases, disorders, or conditions in which modulation or inhibition of 11βHSD1 is beneficial or where a reduction in intracellular glucorticoid levels is desirable.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.