Pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators

US8513436B2 · kind B2 · utility

Assignee

• REATA PHARMACEUTICALS HOLDINGS, LLC · US

Inventors

• Eric Anderson · Cleveland, US
• Gary L. Bolton · Ann Arbor, US
• Bradley W. Caprathe · Redford, US
• Xin Jiang · Coppell, US
• Chitase Lee · Ann Arbor, US
• William H. Roark · Ann Arbor, US
• Melean Visnick · Irving, US

Key dates

• Filing date: Dec 19, 2011
• Grant date: Aug 20, 2013
• Expiry date: Dec 19, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D487/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed herein are novel antioxidant inflammation modulators, including those of the formula:wherein the variables are defined herein. Also provided are pharmaceutical compositions, kits and articles of manufacture comprising such compounds. Methods and intermediates useful for making the compounds, and methods of using the compounds and compositions thereof are also provided.