Patent · US Active

High eicosapentaenoic acid producing strains of Yarrowia lipolytica

US8518674B2 · kind B2 · utility

0Cited by

7References

15Claims

0Family size

Assignee

E.I. DU PONT DE NEMOURS AND COMPANY · US

Inventors

Howard Glenn Damude
Peter John Gillies · Landenberg, US
Daniel Joseph Macool · Rutledge, US
Stephen Picataggio · Rockland, US
Dana M. Walters Pollak · West Chester, US
James John Ragghianti · Bear, US
Zhixiong Xue · Chadds Ford, US
Narendra S. Yadav · Wilmington, US
Hongxiang Zhang · Chadds Ford, US
Quinn Qun Zhu · West Chester, US

Key dates

Filing date	Sep 29, 2010
Grant date	Aug 27, 2013
Priority date	—
Expiry date	May 16, 2031

Classification

Technology area (CPC A)Human Necessities
CPC primaryA23V2002/00
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Engineered strains of the oleaginous yeast Yarrowia lipolytica capable of producing greater than 25% eicosapentaenoic acid (EPA, an ω-3 polyunsaturated fatty acid) in the total oil fraction are described. These strains comprise various chimeric genes expressing heterologous desaturases, elongases and acyltransferases and optionally comprise various native desaturase and acyltransferase knockouts to enable synthesis and high accumulation of EPA. Production host cells are claimed, as are methods for producing EPA within said host cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.