Strain comprising increased expression of a CFA coding region for butanol production
US8518678B2 · kind B2 · utility
35Cited by
4References
26Claims
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Key dates
| Filing date | Dec 9, 2008 |
| Grant date | Aug 27, 2013 |
| Priority date | — |
| Expiry date | Jan 24, 2030 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02E50/10
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Screening of fatty acid fed bacteria which are not natural butanol producers identified increased membrane cyclopropane fatty acid as providing improved butanol tolerance. Increasing expression of cyclopropane fatty acid synthase in the presence of the enzyme substrate that is either endogenous to the cell or fed to the cell, increased butanol tolerance. Bacterial strains with increased cyclopropane fatty acid synthase and having a butanol biosynthetic pathway are useful for production of butanol.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.