Bifunctional polyazamacrocyclic chelating agents
US8518715B2 · kind B2 · utility
0Cited by
5References
15Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 21, 2012 |
| Grant date | Aug 27, 2013 |
| Priority date | — |
| Expiry date | May 21, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D471/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A bifunctional polyazamacrocyclic chelating agent of the formula (I):wherein:and the variables A, L, Q, Q1, X, Y, Z, Z1, m, n and r are as defined in the description of the present application. Also described is a complex of the above chelating agent to an ion of a metal ion, such as an ion of 90Y, 111In or 177Lu; a conjugate of the complex covalently attached to a biological carrier; and a pharmaceutical composition containing the conjugate. A method of therapeutic treatment of a mammal involving administration of the pharmaceutical composition is also described.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.