Cytoprotective thereapeutic agents for the prevention of reperfusion injury following ischemic stroke
US8518886B2 · kind B2 · utility
1Cited by
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9Claims
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Key dates
| Filing date | Apr 19, 2011 |
| Grant date | Aug 27, 2013 |
| Priority date | — |
| Expiry date | Apr 19, 2031 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61P39/06
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates generally to the use of γ-glutamyl antioxidants, particularly γ-glutamyl-cysteine, as cytoprotective agents to prevent reperfusion injury (i.e., hemorrhagic transformation) of the blood-brain barrier during reperfusion following an ischemic stroke. The γ-glutamyl antioxidants can be used alone or used in combination with an agent which inhibits the reverse movement of Na/Ca exchange in the blood-brain barrier such as 2-[2-[4-(4-nitrobenzyloxy)phenyl]ethyl]isothiourea methanesulphonate (KB-R7943).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.