Pyrido [2,3-D] pyrimidines and their use as kinase inhibitors

US8518958B2 · kind B2 · utility

Assignee

• FORMA Therapeutics, Inc. · US

Inventors

• Krishna Murthi · Cambridge, US
• Rebecca Casaubon · Cambridge, US
• Arthur F. Kluge · Lincoln, US
• Chase C. Smith · Rutland, US
• Joachim Vogt · Munich, DE

Key dates

• Filing date: Oct 16, 2007
• Grant date: Aug 27, 2013
• Expiry date: Feb 12, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P35/00
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention provides derivatives of pyrido[2,3-d]pyrimidin-7-one. These compounds are kinase inhibitors, including compounds that show anti-proliferative activity, including against tumor cells, and are useful in the treatment of diseases including cancer.