Netrin-1 compositions and methods of use thereof
US8524228B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Nov 3, 2008 |
| Grant date | Sep 3, 2013 |
| Priority date | — |
| Expiry date | Mar 2, 2030 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/367
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Methods and compositions for male or female contraception are provided. The compositions include an effective amount of netrin-1 to reduce or inhibit sperm concentration in semen of males or to inhibit or reduce fusion of male gametes with female gametes in a female subject Still another embodiment provides a method for diagnosing male infertility by determining the amount of netrin-1 in a sample of epididymal fluid or semen from a male subject, comparing the amount of netting-1 in the sample to levels of netrin-1 in samples of epididymal fluid or semen from fertile males, wherein levels of netrin-1 in the sample from the male subject that are higher or lower than levels of netrin-1 in samples from fertile males are indicative of male infertility in the male subject.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.