Arylamine ketones, their preparation methods, the pharmaceutical composition containing them and their use

US8524744B2 · kind B2 · utility

Assignee

• INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES · CN

Inventors

• Liya Zhu · Nanjing, CN
• Wenjie Wang · Beijing, CN
• Halhong Huang · Beijing, CN
• Ziyun Lin · Beijing, CN
• Liyuan Mou · Beijing, CN
• Zhengui Nie · Beijing, CN
• Yu He · Beijing, CN
• Xueyu Ouyang · Beijing, CN
• Shanying Peng · Beijing, CN
• Dongfong Zhang · Beijing, CN
• Jun Wei · Baofeng County, CN

Key dates

• Filing date: Aug 5, 2005
• Grant date: Sep 3, 2013
• Expiry date: Nov 25, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D405/06
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed Arylamine ketones of formula (I), their preparation methods, the pharmaceutical compositions containing them and their use in preventing and/or treating the diseases related to the plaque-activating factors, especially in anti-inflammation and immunization, more especially in the treatment of the acute or chronic inflammation, such as, osteoarthritis, oarthritis deformans, etc.