Organosulfur compounds, a method of making organosulfur compounds and their use for inhibiting the growth of tumour cells

US8524781B2 · kind B2 · utility

Assignee

• UNIVERSITY OF CAPE TOWN · ZA

Inventors

• Catherine Hart Kaschula · Cape Town, ZA
• Roger Hunter · Bakersfield, US
• Mohamed Iqbal Parker · Cape Town, ZA

Key dates

• Filing date: Aug 5, 2009
• Grant date: Sep 3, 2013
• Expiry date: Nov 4, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D209/48
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Organosulfur compounds of the general formula (2) are described, wherein R1 and R2 are linear or branched C1-C5 alkyl; linear or branched C1-C5 alkenyl with the proviso that R1 is not prop-1-enyl (allyl); substituted linear or branched C1-C5 alkenyl or substituted linear or branched C1-C5 alkyl, in which the substituents are selected from OR3, NR4R5, COOR6, CON—R7R8, in which R3 is selected from H, COR9, para-methoxybenzyl and trialkylsilyl, in which R9 is alkyl or substituted alkyl; R4 N and R5 are alkyl or R4 and R5 together form a phthalimido group; R6 is alkyl or substituted alkyl; and R7 and R8 are alkyl or substituted alkyl; substituted or unsubstituted aromatic specifically where R1 and R2 are benzyl, para-methoxybenzyl and/or ortho,para-methoxybenzyl and substituted or unsubstituted heteroaromatic. The compounds can be used for inhibiting the growth of tumor cells and for treating cancer. A pharmaceutical composition and a method of preparing the compounds are also described.