Amyloid-beta peptide crystal structure
US8524863B2 · kind B2 · utility
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23Claims
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Key dates
| Filing date | Oct 6, 2009 |
| Grant date | Sep 3, 2013 |
| Priority date | — |
| Expiry date | Oct 6, 2029 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B15/00
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates provides a novel crystal structure of the fibrillogenic part of amyloid β-peptide (Aβ). More specifically the crystal structure is Aβ-IgNAR and, accordingly the present invention also relates to selecting and/or designing compounds that modulate amyloid β-peptide (Aβ) activity using techniques such as in silico screening and crystal soaking experiments. The invention further relates to compounds and methods for inhibiting interaction between amyloid β-peptide (Aβ) monomers, more particularly, inhibiting or disrupting amyloid β-peptide (Aβ) oligomer formation and toxic activity.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.