Humanized antibodies against LIGHT and uses thereof

US8524869B2 · kind B2 · utility

Assignee

• TEV A Biopharmaceuticals USA, Inc. · US

Inventors

• Rodger Smith · Jefferson, US
• Palanisamy Kanakaraj · Germantown, US
• Bridget A. Cooksey · Rockville, US
• Viktor Roschke · Rockville, US
• Craig Rosen · Laytonsville, US

Key dates

• Filing date: Mar 22, 2010
• Grant date: Sep 3, 2013
• Expiry date: Mar 22, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/34
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present invention is directed to antigen-binding polypeptides, or variants or derivatives thereof which specifically bind the LIGHT polypeptide. The invention is also directed to methods of making and using such antibodies specifically in the treatment or diagnosis of immune, inflammatory and malignant diseases or conditions (e.g. inflammatory bowel disease; Crohn's disease, ulcerative colitis, multiple sclerosis, rheumatoid arthritis and transplantation).