Electrically conductive polymer nanowires with incorporated viruses

US8525237B1 · kind B1 · utility

Assignee

• The Regents of the University of California · US

Inventors

• Gregory A. Weiss · Irvine, US
• Reginald M. Penner · Newport Beach, US
• Jessica A. Arter · Irvine, US
• David K. Taggart · Mission Viejo, US
• Keith C. Donavan · Irvine, US

Key dates

• Filing date: Oct 3, 2011
• Grant date: Sep 3, 2013
• Expiry date: Oct 3, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N27/127
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

Grafting M13 bacteriophage into an array of poly(3,4-ethylenedioxythiophene) (PEDOT) nanowires generated hybrids of conducting polymers and replicable genetic packages (rgps) such as viruses. The incorporation of rgps into the polymeric backbone of PEDOT occurs during electropolymerization via lithographically patterned nanowire electrodeposition (LPNE). The resultant arrays of rgps-PEDOT nanowires enable real-time, reagent-free electrochemical biosensing of analytes in physiologically relevant buffers.