Patent · US Active

Amperometric sensor and method for its manufacturing

US8527024B2 · kind B2 · utility

3Cited by

11References

29Claims

0Family size

Assignee

Roche Diagnostics Operations, Inc. · US

Inventors

Arnulf Staib · Heppenheim, DE
Reinhold Mischler · Ludwigshafen, DE
Martin Hajnsek · Graz, AT
Harvey Buck · Indianapolis, US
Walter Jernigan · Indianapolis, US

Key dates

Filing date	Dec 19, 2008
Grant date	Sep 3, 2013
Priority date	—
Expiry date	Apr 17, 2031

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/001
WIPO fieldMedical technology
WIPO sectorInstruments

Abstract

An in vivo amperometric sensor is provided for measuring the concentration of an analyte in a body fluid. The sensor comprises a counter electrode and a working electrode, and the working electrode comprises a sensing layer which is generally water permeable and arranged on a support member adjacent to a contact pad. The sensing layer comprises an immobilized enzyme capable of acting catalytically in the presence of the analyte to cause an electrical signal. The sensing layer has an upper surface facing the body fluid and a lower surface facing away from the body fluid, and the immobilized enzyme is distributed within the sensing layer in such a way that the enzyme concentration in the middle between the upper and lower surfaces is at least as high as on the upper surface of the sensing layer.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.