Soluble inhibitors of vascular endothelial growth factor and use thereof
US8529905B2 · kind B2 · utility
4Cited by
8References
4Claims
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Key dates
| Filing date | Apr 8, 2010 |
| Grant date | Sep 10, 2013 |
| Priority date | — |
| Expiry date | Apr 8, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K48/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to cDNA encoding a soluble neuropilin protein (sNP) which is isolated from neuropilin (NP) producing cells or is recombinantly engineered from NP-encoding DNA. NP-1 and NP-2 are preferred NPs but any neuropilin or VEGF receptor (VEGFR), where the constituents share at least about 85% homology with either of the above VEGF165R/NP-1 and NP-2. More preferably, such constituent shares at least 90% homology. Still more preferably, each constituent shares at least 95% homology.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.