Small Streptococcus pyogenes antigens and their use

US8529911B2 · kind B2 · utility

Assignee

• Intercell Austria AG · AT

Inventors

• Andreas Meinke · Pressbaum, AT
• Eszter Nagy · Wien, AT
• Alexander Von Gabain · Wien, AT
• Manfred Berger · Wiener Neustadt, AT
• Beatrice Senn · Wien, AT
• Michael Schunn · Wien, AT

Key dates

• Filing date: Jul 6, 2007
• Grant date: Sep 10, 2013
• Expiry date: Feb 7, 2028

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K39/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a peptide consisting of one antigen of Streptococcus pyogenes (S. pyogenes) of any of the SEQ ID NOS: 1 to 7 or a functional active variant thereof, optionally further consisting of additional amino acid residue(s); a nucleic acid coding for the same; a pharmaceutical composition, especially a vaccine, comprising said peptide or said nucleic acid; an antibody or functional active fragment thereof specifically binding to the antigen; a hybridoma cell line which produces said antibody; a method for producing said antibody; a pharmaceutical composition comprising said antibody; the use of said peptide or said nucleic acid for the manufacture of a medicament for the immunization or treatment of a subject; the use of said antibody or functional fragment thereof for the manufacture of a medicament for the treatment of an infection; a method of diagnosing a S. pyogenes infection; a method for identifying a ligand capable of binding to said peptide; and the use of said peptide for the isolation and/or purification and/or identification of an interaction partner of the peptide.