Patent · US Active

G-protein coupled receptor kinase-5 polymorphism

US8530160B2 · kind B2 · utility

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4Claims
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Assignee

Inventors

Key dates

Filing dateSep 10, 2007
Grant dateSep 10, 2013
Priority date—
Expiry dateSep 24, 2027

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q1/6827
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present invention is directed to compositions and methods relating to a G-protein coupled receptor kinase-5 polymorphism. The methods include, for example: detecting enhanced desensitization of the beta adrenergic receptor signaling pathway in an individual, assessing partial protection against heart failure progression in an individual, and assessing an individual's response to beta-blocker therapy. The compositions include polynucleotides or fragments thereof of a nucleotide sequence encoding for a G-protein receptor kinase-5 molecule with a thymine at amino acid position 122 and oligonucleotide primers that hybridize thereto.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.