Electrochemical methods of detecting cancer with 4-aminophenyl phosphate
US8530179B2 · kind B2 · utility
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2References
13Claims
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Key dates
| Filing date | Jul 18, 2012 |
| Grant date | Sep 10, 2013 |
| Priority date | — |
| Expiry date | Jul 18, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q1/42
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A method of detecting cancer cells is disclosed. The method comprises (a) contacting the cell which is suspicious of a cancerous or undifferentiated phenotype with 4-aminophenyl phosphate (p-APP) under conditions wherein alkaline phosphatase of the cell catalyzes a reaction of the cell with the p-APP, so as to generate a product capable of producing an electrical signal; and (b) measuring a level of the electrical signal, wherein a difference in a level of the electrical signal compared to a predetermined threshold is indicative of a cancer cell.
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