Piperazinyl and piperidinyl ureas as modulators of fatty acid amide hydrolase

US8530476B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Richard Apodaca · San Diego, US
• J. Guy Breitenbucher · Escondido, US
• Kanaka Pattabiraman · Los Altos, US
• Mark Seierstad · Escondido, US
• Wei Xiao · San Diego, US

Key dates

• Filing date: Sep 11, 2009
• Grant date: Sep 10, 2013
• Expiry date: Nov 28, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D417/12
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Certain piperazinyl and piperidinyl urea compounds are useful as FAAH inhibitors. Such compounds may be used in pharmaceutical compositions and methods for the treatment of disease states, disorders, and conditions mediated by fatty acid amide hydrolase (FAAH) activity. Thus, the compounds may be administered to treat, e.g., anxiety, pain, inflammation, sleep disorders, eating disorders, or movement disorders (such as multiple sclerosis).