2, 5-diamino-substituted pyrido [4, 3-D] pyrimidines as autotaxin inhibitors against cancer

US8530650B2 · kind B2 · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Kai Schiemann · Darmstadt, DE
• Melanie Schultz · Darmstadt, DE
• Wolfgang Staehle · Ingelheim am Rhein, DE
• Ingo Kober · Groß-Gerau, DE
• Dirk Wienke · Darmstadt, DE
• Mireille Krier · Mühltal, DE

Key dates

• Filing date: Nov 3, 2009
• Grant date: Sep 10, 2013
• Expiry date: Nov 19, 2029

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P37/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to pyridopyrimidine derivatives according to formula (I) as autotaxin inhibitors and the use of such compounds for the treatment and/or prophylaxis of physiological and/or pathophysiological conditions, which are caused, mediated and/or propagated by increased lysophosphatic acid levels and/or the activation of autotaxin, in particular of different cancers.