Detection and reduction of phrenic nerve stimulation

US8532774B1 · kind B1 · utility

Assignee

• ST. JUDE MEDICAL AB · SE

Inventors

• Sven-Erik Hedberg · Kungsängen, SE
• Tomas Svensson · Bunkeflo, SE
• Kjell Noren · Solna, SE
• Stuart Rosenberg · Santa Clarita, US
• Kyungmoo Ryu · Palmdale, US
• Edward Karst · Los Angeles, US

Key dates

• Filing date: Jul 10, 2012
• Grant date: Sep 10, 2013
• Expiry date: Jul 10, 2032

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61N1/3702
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

The present invention provides methods for detecting phrenic nerve stimulation. A pacing module is instructed to deliver pacing pulses having a predetermined pulse amplitude and/or width within the refractory period of the left ventricle. The pacing pulses are repeatedly delivered during a number of cardiac cycles and wherein the pacing pulses are delivered at different delays relative to an onset of the refractory period of the left ventricle in different cardiac cycles. Impedance signals are measured in time windows synchronized with the delivery of pacing pulses in the refractory period of the left ventricle using at least one electrode configuration. At least one impedance signal is gathered from each time window, aggregated impedance signals are created using the impedance signals from the different time windows, and the aggregated impedance signals are analyzed to detect PNS.