Methods of treating lupus by administering humanized anti-interleukin 3 receptor alpha chain antibodies

US8535669B2 · kind B2 · utility

Assignee

• CSL LIMITED · AU

Inventors

• Gino Luigi VAIRO · Melbourne, AU
• Andrew Donald Nash · Melbourne, AU
• Eugene Maraskovsky · Melbourne, AU
• Nick WILSON · Melbourne, AU
• Samantha J. Busfield · Kelmscott, AU

Key dates

• Filing date: Feb 17, 2011
• Grant date: Sep 17, 2013
• Expiry date: Feb 17, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/76
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides a method for treating lupus, Sjörgen's syndrome or scleroderma, the method comprising administering to the mammal an immunoglobulin which binds an interleukin 3 receptor α (IL-3Rα) chain and which depletes or at least partly eliminates plasmacytoid dendritic cells (p DCs) and basophils to which it binds.