Identification of bacterial autoinducer and use in treating bacterial pathogenicity

US8535689B2 · kind B2 · utility

Assignee

• THE TRUSTEES OF PRINCETON UNIVERSITY · US

Inventors

• Bonnie L. Bassler · Princeton, US
• Martin F. Semmelhack · Princeton, US
• Douglas Higgins · Berkeley, US
• Megan Eileen Bolitho · San Mateo, US
• Kristina M. Kraml · Princeton, US
• Wai-Leung Ng · Lawrenceville, US

Key dates

• Filing date: Oct 1, 2008
• Grant date: Sep 17, 2013
• Expiry date: Aug 13, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/07
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A bacterial autoinducer, CAI-1, was purified and its structure identified. Methods for synthesis of the autoinducer and its analogues were elucidated. Methods of using the autoinducer or its analogues for treating bacterial pathogenicity and bio film formation are described. Methods for prevention and treatment of cholera are described. Synthetic (S)-3-hydroxytridecan-4-one functions as well as natural CAI-1 in repressing production of the virulence factor toxin co-regulated pilus (TCP). Strategies are described to manipulate bacterial quorum sensing in the clinical arena.