Medical devices having porous polymeric regions for controlled drug delivery and regulated biocompatibility
US8535702B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Feb 1, 2005 |
| Grant date | Sep 17, 2013 |
| Priority date | — |
| Expiry date | Jul 29, 2030 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61N1/05
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
The present invention relates to phase separated polymeric regions and to their use in conjunction with implantable or insertable medical devices. In some aspects of the invention, phase separated polymeric regions are provided that include (a) at least one biostable polymeric phase and (b) at least one biodisintegrable polymeric phase, which is of nanoscale dimensions and which undergoes biodisintegration such that the phase separated polymeric region becomes a nanoporous polymeric region in vivo. Other aspects of the invention are directed to methods of making implantable or insertable medical devices having at least one nanoporous polymeric region. These methods include (a) providing a phase separated polymeric region comprising a stable polymeric phase and a disintegrable polymeric phase of nanoscale dimensions, (b) selectively removing the disintegrable polymeric phase thereby producing the nanoporous polymeric region. In still other aspects, implantable or insertable medical devices are provided which have phase separated polymeric regions that include (a) at least one block copolymer having at least one biostable polymer block and at least one biodisintegrable polymer block …
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.