Oxidant resistant apolipoprotein A-1 and mimetic peptides
US8536117B2 · kind B2 · utility
7Cited by
6References
16Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | Feb 14, 2012 |
| Grant date | Sep 17, 2013 |
| Priority date | — |
| Expiry date | Feb 14, 2032 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K38/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for the treatment of cardiovascular disease or disorder in a subject in need thereof, the method comprising the steps of administering an ApoA1 mimetic that is capable of promoting cholesterol efflux from lipid loaded cells in the subject, wherein the ApoA1 mimetic has an amino acid sequence that includes at least a portion of the amino acid sequence of ApoA1 or a mimetic of ApoA1 that contains at least one tryptophan, at least one tryptophan from the ApoA1 or mimetic of the ApoA1 being substituted with an oxidant resistant amino acid in the amino acid sequence of the ApoA1 mimetic.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.