Selective high-affinity polydentate ligands and methods of making such

US8536133B2 · kind B2 · utility

Assignees

• Lawrence Livermore National Security, LLC · US
• The Regents of the University of California · US

Inventors

• Sally J. DeNardo · El Macero, US
• Gerald L. DeNardo · El Macero, US
• Rodney L. Balhorn · Livermore, US

Key dates

• Filing date: Dec 18, 2009
• Grant date: Sep 17, 2013
• Expiry date: Jul 4, 2031

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N33/574
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

This invention provides polydentate selective high affinity ligands (SHALs) that can be used in a variety of applications in a manner analogous to the use of antibodies. SHALs typically comprise a multiplicity of ligands that each binds different regions on the target molecule. The ligands are joined directly or through a linker thereby forming a polydentate moiety that typically binds the target molecule with high selectivity and avidity.