Compounds having CRTH2 antagonist activity

US8536158B2 · kind B2 · utility

Assignee

• ATOPIX THERAPEUTICS LIMITED · GB

Inventors

• Richard Edward Armer · Shrewsbury, GB
• Eric Roy Pettipher · Shrewsbury, GB
• Mark Whittaker · Felton, GB
• Graham Michael Wynne · Walsall, GB
• Julia Vile · Shrewsbury, GB
• Frank Schroer · Shrewsbury, GB

Key dates

• Filing date: Jan 26, 2011
• Grant date: Sep 17, 2013
• Expiry date: Feb 1, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D401/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Compounds of general formula (I)whereinW is chloro or fluoro;R1 is phenyl optionally substituted with one or more substituents, selected from halo, —CN, —C1-C6 alkyl, —SOR3, —SO2R3, —SO2N(R2)2, —N(R2)2, —NR2C(O)R3, —CO2R2, —CONR2R3, —NO2, —OR2, —SR2, —O(CH2)pOR2, or —O(CH2)pO(CH2)qOR2 wherein