Pyrimidine inhibitors of kinase activity

US8536180B2 · kind B2 · utility

Assignee

• Abb Vie Inc. · US

Inventors

• Richard F. Clark · Mundelein, US
• Nwe Y. Ba-maung · Niles, US
• Scott A. Erickson · Zion, US
• Steve D. Fidanze · Grayslake, US
• Robert A. Mantei · Franklin, US
• George S. Sheppard · Wilmette, US
• Bryan K. Sorensen · Antioch, US
• Gary T. Wang · Libertyville, US
• Jieyi Wang · Lake Bluff, US
• Randy L. Bell · Lindenhurst, US

Key dates

• Filing date: May 26, 2010
• Grant date: Sep 17, 2013
• Expiry date: Jun 12, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D513/04
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Described herein are compounds of formula (I) or pharmaceutical acceptable salts or solvates thereof,wherein G1, L1, R2, R3, n, p, Ar1, and Ar2 are defined in the description. Methods of making said compounds, and compositions comprising said compounds which are useful for inhibiting kinases such as IGF-1R are also disclosed.