Patent · US Active

Method of drug delivery by carbon nanotube-chitosan nanocomplexes

US8536324B2 · kind B2 · utility

1Cited by

4References

18Claims

0Family size

Assignee

University of South Florida · US

Inventors

Shyam S. Mohapatra · Lutz, US
Arun Kumar · Tampa, US

Key dates

Filing date	Apr 18, 2008
Grant date	Sep 17, 2013
Priority date	—
Expiry date	Jul 2, 2030

Classification

Technology area (CPC Y)Emerging Cross-Sectional Technologies
CPC primaryY10S977/753
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Functionalized Single Wall Carbon Nanotube (SWCNT) complexed with nanochitosan for use in the delivery of bioaffecting substances and diagnostic applications. fSWCNT complexed with the chitosan NG042 were used for delivery of DNA-encoding EGFP reporter protein and peptide. The results demonstrate that shown CNT-chitosan hybrid nanoparticles exhibit significantly higher transfection efficiency in vivo than chitosan alone. Furthermore, the functionalized nanotubes were tested for peptide transfer into HEK293 cells. The results showed that the hybrid nanoparticles efficiently transferred peptides. Together, these results show that hybrid SWCNT-chitosan particles increase DNA and peptide transfer into cells.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.