Process for making substituted 2-amino-thiazolones

US8536345B2 · kind B2 · utility

Assignee

• AMGEN INC. · US

Inventors

• George A. Moniz · Cambridge, US
• Matthew J. Frizzle · Dundas, CA
• Charles Bernard · Moorpark, US
• Michael John Martinelli · Indianapolis, US
• Margaret Mary Faul · Zionsville, US
• Jay Larrow · Wakefield, US
• Karl Hansen · Atlantic Highlands, US
• Liane Klingensmith · Stoughton, US

Key dates

• Filing date: Jun 16, 2009
• Grant date: Sep 17, 2013
• Expiry date: Jun 16, 2029

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D277/42
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

The present invention relates to methods of making compounds that inhibit 11-β-hydroxysteroid dehydrogenase type 1 enzyme (11-β HSD1). One method comprises (a) contacting a compound of formula (II) with a chiral base, deprotonating agent, and an alkylating agent R3-LG, (b) contacting the product of (a) with an acid to form a salt, and (c) reacting the salt with a base to form the compound of formula (I); wherein Z, R1, R2, and R3 are defined herein.