Formation of nitrate esters in microreactors and millireactors using a continuous product extraction in a turbulent flow regime

US8536366B2 · kind B2 · utility

Assignee

• DSM Fine Chemicals Austria NFG GmbH & Co KG · AT

Inventors

• Sascha Braune · Luftenberg an der Donau, AT
• Stefan Steinhofer · Ansfelden, AT
• Peter Poechlauer · Linz, AT
• Rafael Wilhelmus Elisabeth Ghislain Reintjens · Echt, NL
• Nicole Theodora W. Linssen · Kessenich, BE
• Mehul Thathagar · Geleen, NL

Key dates

• Filing date: Dec 19, 2008
• Grant date: Sep 17, 2013
• Expiry date: Feb 8, 2030

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2219/00984
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A process for the continuous production of a compound of Formula (II), HO—R1—ONO2 (II) wherein R1 is a straight chain alkyl radical having from 3 to 6 carbon atoms, in a two-phase solvent system, comprising contacting a compound of Formula (I), HO—R1—OH (I) wherein R1 is as defined above, with nitric acid in the presence of a first solvent, wherein the compound of Formula (II) is continuously extracted into a second solvent, and the reaction is carried out in a mixing microreactor which provides a power loss of at least 1.3 times the power loss provided under identical conditions by a circular cross-section straight-channel microreactor having an internal diameter equal to the average hydraulic diameter of the mixing microreactor and a length equal to the length of the mixing microreactor.