Patent · US Active

Method of production of 9-cis-retinoic acid

US8536373B2 · kind B2 · utility

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2References

7Claims

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Assignee

DSM IP ASSETS B.V. · NL

Inventors

Michael Stanek · San Clemente, US
Stefan Essl · Binzen, DE
Monika Knopp · Ludwigshafen, DE
Erwin Kübel · Linz, AT

Key dates

Filing date	Sep 27, 2007
Grant date	Sep 17, 2013
Priority date	—
Expiry date	Feb 17, 2030

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C2601/16
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Improved method of production of 9-(Z)-retinoic acid, in which a) a β-formyl-crotonic acid C1-C10 alkyl or phenyl ester is reacted with an isolated 9-(Z)—C15-triarylphosphonium salt by the Wittig reaction in the presence of a base to the corresponding 9-(Z)-retinoic acid ester; which b) is then saponified with a base to the corresponding 9-(Z)-retinoic acid carboxylate and then, following protonation with an acid, the desired 9-(Z)-retinoic acid is obtained, and improved method for the enrichment and isolation of the 9-(Z)—C15-triarylphosphonium salt.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.