Single wall nanotube constructs and uses therefor

US8540965B2 · kind B2 · utility

Assignee

• Sloan Kettering Institute for Cancer Research · US

Inventors

• David A. Scheinberg · New York, US
• Michael R. McDevitt · New York, US
• Christophe Antczak · Arlington, US
• Debjit Chattopadhyay · Pennington, US
• Rena May · Baltimore, US
• Jon Njardarson · Tucson, US
• Mark R. Philips · New York, US

Key dates

• Filing date: Jul 31, 2006
• Grant date: Sep 24, 2013
• Expiry date: Sep 10, 2028

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C01B2202/36
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides soluble single wall nanotube constructs functionalized with a plurality of a targeting moiety and a plurality of one or more payload molecules attached thereto. The targeting moiety and the payload molecules may be attached to the soluble single wall carbon nanotube via a DNA or other oligomer platform attached to the single wall carbon nanotube. These soluble single wall carbon nanotube constructs may comprise a radionuclide or contrast agent and as such are effective as diagnostic and therapeutic agents. Methods provided herein are to diagnosing or locating a cancer, treating a cancer, eliciting an immune response against a cancer or delivering an anticancer drug in situ via an enzymatic nanofactory using the soluble single wall carbon nanotube constructs.