Methods of generating immune responses with compositions comprising an adenoviral expression vector comprising a CD40L fusion protein
US8540979B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 16, 2012 |
| Grant date | Sep 24, 2013 |
| Priority date | — |
| Expiry date | Jul 16, 2032 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2710/20071
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are adenoviral vectors for generating an immune response to antigen. The vectors comprise a transcription unit encoding a secretable polypeptide, the polypeptide comprising a secretory signal sequence upstream of a tumor antigen upstream of CD40 ligand, which is missing all or substantially all of the transmembrane domain rendering CD40L secretable. Also provided are methods of generating an immune response against cells expressing a tumor antigen by administering an effective amount of the invention vector. Further provided are methods of generating an immune response against cancer expressing a tumor antigen in an individual by administering an effective amount of the invention vector. Still further provided are methods of generating immunity to infection by human papilloma virus (HPV) by administering an effective amount of the invention vector which enocodes the E6 or E7 protein of HPV. The immunity generated is long term.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.