Vectors expressing SARS immunogens, compositions containing such vectors or expression products thereof, methods and assays for making and using

US8541003B2 · kind B2 · utility

Assignee

• Protein Sciences Corporation · US

Inventors

• D. Karl Anderson · Meriden, US
• Kathleen M. Holtz-Corris · Cheshire, US
• Rick Chubet · Middletown, US
• Daniel Adams · Berkeley Heights, US
• Manon Cox · East Haven, US

Key dates

• Filing date: Jun 21, 2004
• Grant date: Sep 24, 2013
• Expiry date: Jun 4, 2026

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2800/26
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

SARS (severe acute respiratory syndrome virus, a coronavirus) immunogens, antigens, or epitopes, nucleic acid molecules encoding such immunogens, antigens, or epitopes; vectors containing such nucleic acid molecules, e.g., viral vectors such as baculovirus vectors, DNA vectors, such as DNA plasmid vectors, e.g., DNA plasmids that express a nucleic acid molecule in a mammalian cell, uses for such immunogens, antigens or epitopes and vectors, e.g., as an active component immunogenic, immunological or vaccine compositions, or to generate antibodies, such as monoclonal antibodies, and methods for making, and using such immunogens, antigens or epitopes, vectors, antibodies, including in methods for eliciting an immunological or immunogenic or vaccine response, as well as in assays or diagnostic kits or methods, are discussed, as well as a seamless fusion of sequences in a plasmid or vector, e.g., a sequence encoding a leader sequence and a sequence encoding a protein, epitope or immunogen or antigen.