Inhibitors of the human aldosterone synthase CYP11B2

US8541404B2 · kind B2 · utility

Assignee

• ElexoPharm GmbH · DE

Inventors

• Rolf Hartmann · Saarburg, DE
• Ralf Heim · Riegelsberg, DE
• Simon Lucas · Wien, AT

Key dates

• Filing date: Nov 3, 2010
• Grant date: Sep 24, 2013
• Expiry date: Jan 30, 2031

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D471/06
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The invention provides compounds of the general formula (I)which are inhibitors of the human aldosterone synthase, and also pharmaceutical compositions containing these compounds, and a method of treating of hyperaldosteronism and/or disorders or diseases that are mediated by 11β-hydroxylase (CYP11B1) with these compounds.