Targeting an HIV-1 nef-host cell kinase complex
US8541415B2 · kind B2 · utility
2Cited by
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5Claims
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Key dates
| Filing date | May 14, 2009 |
| Grant date | Sep 24, 2013 |
| Priority date | — |
| Expiry date | Oct 26, 2029 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D491/04
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Drug candidates for inhibition of HIV-I replication can target Src family kinases (SFK), such as Hck, that interact with Nef protein of the virus. Compounds characterized by such inhibitory activity were identified via an assay for kinase activity of an SFK in a Nef:SFK complex. Illustrative of inhibitors identified using the kinase assay are various 2,3-diaminoquinaxolines and furo[2,3-d]pyrimidines. The inventive inhibitors were found to arrest HIV-I viral replication in vitro.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.