Inhibitors of polo-like kinase

US8541418B2 · kind B2 · utility

Assignee

• Elan Pharmaceuticals, Inc. · US

Inventors

• Robert A. Galemmo, Jr. · San Francisco, US
• Dean R. Artis · Kensington, US
• Xiaocong Michael Ye · Palo Alto, US
• Danielle Aubele · Burlingame, US
• Anh Truong · Burlingame, US
• Simeon Bowers · Oakland, US
• Roy Hom · San Francisco, US
• Yong-Liang Zhu · Fremont, US
• R. Jeffrey Neitz · San Francisco, US
• Jennifer Sealy · Oakland, US
• Marc Adler · Orinda, US
• Paul Powell Beroza · Belmont, US
• John P. Anderson · Langenfeld, DE

Key dates

• Filing date: Dec 21, 2010
• Grant date: Sep 24, 2013
• Expiry date: Dec 21, 2030

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides compounds having a structure according to Formula (I):or a salt or solvate thereof, wherein ring A, E1, E2, R1, R2, R3 and R4 are defined herein. The invention further provides pharmaceutical compositions including the compounds of the invention and methods of making and using the compounds and compositions of the invention, e.g., in the treatment and prevention of various disorders, such as Parkinson's disease.